I assume youre talking about changing a node in an XML document on disk? The only way I know of is to load the XML into an XmlDocument, locate the right node with XPath (probably selectSingleNode) and then change its text (or is it nodeText) property. You probably dont want innerText in case there are nested nodes - the innerText will contain all of the inner text, not just for your node. Finally, youll have to save the XML back to file.
-ner